The active ingredient used in the diet pill of Zafgen (ZGN, 433) was originally developed by a South Korean pharmaceutical (CKD Pharmaceuticals) to treat solid tumors in cancer cases. It works by increasing the breakdown of fat. Zafgen CKD Pharmaceuticals has bought the exclusive rights to use ZGN-433 in the world (except South Korea).
Various scientific studies have suggested that the more overweight you become, the more your body will struggle to change its composition because the body becomes “programmed” to produce and store more fat. This makes the body less sensitive to the insulin hormone (a hormone that helps us to fight against excess weight because it encourages the body to burn fat).
The researchers say that the Zafgen ZGN-433 diet pill blocks an enzyme called MetAP2. This enzyme is harmful because it prevents many genes that are important to function properly. This enzyme MetAP2 indirectly promotes insulin resistance, excessive fat, inflammation, various health problems related to obesity. In fact, scientists believe their Zafgen drug works because it resets the way the body metabolizes fat.