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Breast Cancer More Aggressive On Overweight Women

More likely to relapse after treatment, a poorer prognosis … breast cancers are more aggressive among overweight women, but until then we can explain it. But two French research teams are to elucidate this mystery.

In addition to these deleterious effects on cardiovascular health and the onset of diabetes, obesity may play a role in the prognosis of breast cancer, especially its ability to spread to other organs. This statistical relationship is to find a physiological explanation by two research teams bringing together researchers from INSERM, CNRS and Université Paul Sabatier.

An interaction between adipocytes and breast tumor
The outer part of the breast is mainly composed of fatty tissue, itself largely composed of adipocytes. These cells are capable, in addition to their storage / release of fat to secrete many proteins. The researchers investigated whether these proteins play a role in the development of breast cancer.

To do this, teams Philippe Valet at the Institute of metabolic and cardiovascular diseases (Inserm / Université Paul Sabatier) and Catherine Muller at the Institute of Pharmacology and Structural Biology (CNRS / Université Paul Sabatier) cells were grown together mammary tumor and adipocytes.

In the presence of tumor cells, adipocytes change and show a change in the secretion of some of their proteins, including inflammatory proteins such as interleukin 6. Gradually, these cells establish effective interaction with the tumor, which leads to an increase in its “colonization potential”, so its aggressiveness.

 
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Posted by on April 10, 2011 in Breast Cancer

 

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Optimal Cancer Therapy

For optimal cancer therapy, it would be important to know which genes in cancer cells have altered in the patients. In the largest cancer genome study of its kind now, American doctors have sequenced the genomes of tumors from 50 breast cancer patients and compared with the DNA sequences of healthy cells of the same patient.

Surprisingly, the researchers found only a few mutations that occurred with greater frequency. Instead, the varied nature of the mutations between the patients very much. Regardless, the pending analysis of DNA sequences provide important information for better, individual therapy, the scientists said at the annual meeting of the American Association for Cancer Research in Orlando. “Cancer genomes are extremely complicated. This explains the difficulty to predict the treatment outcome and to develop new treatments,” says Matthew Ellis of Washington University in St. Louis, one of the leaders of the project.

Overall, the researchers found more than 1700 mutations. However, most of which came to only one patient. In addition to two known mutations that are present in 40 or 20 percent of cases, researchers identified only three other, previously unknown mutations that were detectable at least ten percent of the tumors. And 21 more altered genes occurred in only two to three patients.

All tumors in the study were estrogen receptor-positive, meaning their growth was strongly stimulated by estrogen. Nevertheless, only in half of cases, effective cancer drug that blocked the estrogen effect. It is not known why the anti-hormonal therapy is effective in some estrogen receptor-positive cancers, and not for others. Detailed analysis of sequence data now available to help you find the cause.

The cancer genome research is an important step towards personalized medicine. It is routinely the tumor genome of the patients are sequenced in the not too distant future after a cancer diagnosis, so that a possible to this type of cancer tailored, optimal therapy.

 
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Posted by on April 4, 2011 in cancer news

 

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Colon Cancer Is Curable

The River War specialist Mary Lang-Lengton said last Thursday at the Club the Province, in the symposium Prevention and treatment of colon cancer, that a liberal intake of red meat, processed meats and foods with a high presence of fats, While reduced consumption of fruits and vegetables, increases the likelihood of colon cancer.

The meeting was organized by the Spanish Association Against Cancer, on the occasion of the celebration last March 31 Day of the disease. Colorectal cancer deaths in Spain are second in the ranking of deaths from cancer in both men and women. The celebration in March this year the European month of Colon Cancer has again underlined the importance of the disease.

For months is visible on billboards and bus shelters, and other advertising media, the campaign of the Alliance for the Prevention of Colon Cancer engaging more than a dozen medical and scientific societies. “Colon cancer is curable in 90 percent of cases if detected early,” said the message signed with several notorious image of Spanish society.
Early detection is essential in this type of tumors, as in other cancers. But perhaps even more the primary prevention of colon cancer as summarized in a healthy lifestyle.

“Diet is key,” said Maria Guerra del Río Lang-Lenton, Deputy Medical Gastroenterology, University Hospital of Gran Canaria Doctor Negrin. “The lifestyle is crucial in the prevention of cancerous diseases of the digestive area and power, definitely,” said the specialist at Club La Province.

 
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Posted by on April 3, 2011 in Colon Cancer

 

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Particular Skin Cancer Heal Without Treatment

Extremely rare, but true: a particular type of skin cancer is able to heal spontaneously without any treatment. Its genetic origin has been identified, which could help the search to discover new cancer therapies.

A tumor that expresses often means the beginning of a long struggle against cancer, based on surgery, chemotherapy, radiotherapy … Therefore the very idea of a cancer cure by itself is somewhat original … but it does exist! This is a skin cancer, very rare, called keratoacanthoma, Ferguson-Smith epithelioma or squamous multiple spontaneously cured (MSSE).

Characterized by the sudden appearance of a tumor at the skin cancer is composed of keratinizing squamous cells, the very ones responsible for the formation of the upper layers of the epidermis. It usually appears during childhood or adolescence or young adulthood, usually on the head. If it heals gradually, leaving more or less visible scars, new tumors often recur periodically.

 
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Posted by on March 14, 2011 in Skin Cancer

 

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Breastfeeding Can Help Protect Children In The Future From Cancer

About 60% of births in Armenia are currently breastfeeding, said Head of the Department of Maternal and Child Health Ministry of Health Karine Saribekian.


“According to 1994 in Armenia, about 20%, ie 20 out of 100 children, were breastfed for up to four months. Over the next three or four years, the number of such children has tripled and even quadrupled. After this index again fell slightly. Currently, about 60% of births in Armenia are breastfed, “- said Saribekian on Thursday at the parliamentary hearings on the issue of breast-feeding children in Armenia.


According to the head of department, breast-feeding not only helps to strengthen the health of both mother and child, but also creates a strong emotional bond between them.


As noted Saribekian, interesting practice doctors apply to women who want to abandon their children in the hospital. “They just give us feed the baby. After that, the vast majority of women take their children “- she said.


As informed Saribekyan, with mother’s milk the child absorbs and information stored at the level of genes. That is why, as stressed by the representative of the Ministry of Health of Armenia, should be encouraged breastfeeding at least six months.


Chairman of the Standing Committee on Health, Maternity and Childhood Ara Babloyan said that breastfeeding can help protect children in the future from such diseases as diabetes, cancer, and the mothers will prevent breast cancer  and ovarian cancer.


“Breastfeeding could save lives of millions of children around the world” – said Babloyan.

 
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Posted by on February 18, 2011 in cancer news

 

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Smoking Are No The Only Lung Cancer Triggerer

Lung cancer triggers not only because of smoking. A number of carcinogenic substances such as asbestos, arsenic, chromate, nickel, chloromethyl ether, radiation, and pollution also can cause lung cancer.


About 90 percent of cases of lung cancer in men and 70 percent in women are due to smoking habits. The more smoke of cigarettes enter the lung, the greater the risk for lung cancer. The cause is because tobacco smoke contains over 4,000 chemicals, and most are carcinogenic and cause cancer.


Two major carcinogenic substances in cigarette tobacco are nitrosamines and polycyclic aromatic hydrocarbons. However, cigarette is not the only cause of lung cancer.

Many who inhaled substances in the workplace which are carcinogenic. For example, asbestos, arsenic, chromate, nickel, chloromethyl ethers, mustard gas, and coke oven emission and radiation can cause lung cancer.

 
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Posted by on January 20, 2011 in cancer news

 

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Soy against 2 cancer, prostate and breast cancer

In addition to flavor our food, soy may also help in the battle against two types of cancer: the breast and the prostate. To detect the two studies were reported by British newspaper the Daily Mail. The first ‘was conducted by a team of researchers at the University of Chicago Northwestern. The results ‘showed that one pill a day of’ genistein ‘, the main isoflavone found in soy, and’ able to slow or stop the spread of prostate cancer.


Although the study involved a small sample of 38 men, scientists believe that these results could lead to the first non-toxic treatment that prevents the movement of cancer cells.

“The first step – said Raymond Bergan, who led the study – and ‘was to see if the drug has the desired effect on the cells and the prostate, and the answer’ it was ‘. If this drug can’ effectively prevent prostate cancer can spread throughout the body, such therapy could theoretically have the same effect on the cells of other types of cancer. “


The second study ‘pro-soy’ and ‘was conducted by the University’ of Buffalo (New York) and involved nearly 1,300 women. The results’ showed that soy isoflavones may reduce the risk of developing breast cancer. Researchers have found that women who consumed more ‘isoflavones have a 30 percent chance’ to be less affected by invasive breast cancer and 60 per cent chance ‘in less than developing cancer’ low degree ‘.


To arrive at these conclusions, the scientists compared the data of 683 women with breast cancer with 611 healthy women. “We have definitely seen – said Anne Weaver, who led the study – a reduction (risk) that deserves further investigation.”

 
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Posted by on January 17, 2011 in cancer news

 

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