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Breast Cancer More Aggressive On Overweight Women

More likely to relapse after treatment, a poorer prognosis … breast cancers are more aggressive among overweight women, but until then we can explain it. But two French research teams are to elucidate this mystery.

In addition to these deleterious effects on cardiovascular health and the onset of diabetes, obesity may play a role in the prognosis of breast cancer, especially its ability to spread to other organs. This statistical relationship is to find a physiological explanation by two research teams bringing together researchers from INSERM, CNRS and Université Paul Sabatier.

An interaction between adipocytes and breast tumor
The outer part of the breast is mainly composed of fatty tissue, itself largely composed of adipocytes. These cells are capable, in addition to their storage / release of fat to secrete many proteins. The researchers investigated whether these proteins play a role in the development of breast cancer.

To do this, teams Philippe Valet at the Institute of metabolic and cardiovascular diseases (Inserm / Université Paul Sabatier) and Catherine Muller at the Institute of Pharmacology and Structural Biology (CNRS / Université Paul Sabatier) cells were grown together mammary tumor and adipocytes.

In the presence of tumor cells, adipocytes change and show a change in the secretion of some of their proteins, including inflammatory proteins such as interleukin 6. Gradually, these cells establish effective interaction with the tumor, which leads to an increase in its “colonization potential”, so its aggressiveness.

 
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Posted by on April 10, 2011 in Breast Cancer

 

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Broccoli Prevent Bladder Cancer

A joint study by researchers in the United States and New Zealand, confirmed the view, long held, that the consumption of cruciferous plants of the family implies a protective effect against cancer. In particular, the research, published in Cancer Research, focused on the action of isothiocyanates, including broccoli sprouts are a rich source on the bladder.

The freeze-dried extract of broccoli sprouts has been administered to laboratory mice, and was able to inhibit the induction of bladder cancer, treated with a carcinogen, a significant and dose-dependent. Inhibition of carcinogenesis was associated with significant induction of protective enzymes against oxidants and carcinogens. On the other hand, the extract itself caused no histological changes in the bladder.

Relevant data that the concentration of isothiocyanates in the urine of mice treated with the extract of broccoli sprouts had two or three times higher than that in the blood. In conclusion, the researchers stress that broccoli sprouts are remarkably promising substances for the prevention of bladder cancer and isothiocyanates, present in the extract are selectively transferred bladder epithelium through urinary excretion.

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Posted by on April 7, 2011 in Bladder Cancer

 

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SPAIN, third largest SMOKERS

SPAIN, third largest SMOKERS


“In fact, until 2000, Spain was at the bottom of Europe in the number of women smokers, but now ranks third.|

In this sense, experts say that the high prevalence should be a compelling reason, not only to enhance smoking cessation plans, regardless of gender, but also to urge the government to achieve greater political commitment to cancer research In order to find new treatments that achieve a cure or improve survival and quality of life of patients.

In his opinion, further steps should target the development of innovation aimed at the definition of clinical criteria and molecular imaging that can identify individuals with higher risk of lung cancer, the development of screening programs as efficient as possible and research of new molecules which may play a role in this struggle.

 
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Posted by on March 3, 2011 in cancer news

 

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